Biological importance and coordination trends of metal complexes of

Biological importance and coordination trends of metal complexes of pyrimidine-2-thione-a Review

I need a review to be written which covers
1. coordination trends i.e. compile the various methods of preparetion of metal complexes of first transition series
2. compile Biological Applications of these metal complexes and other importance if any
3. what is the importance after forming metal complexes which is not in the ligand i.e.pyrimidine-2-thione without metal.
conclusion – what is better and why in author opinion.
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